_Philosophy of Molecular Medicine: Foundational Issues in Theory and Practice_ aims at a systematic investigation of a number of foundational issues in the field of molecular medicine. The volume is organized around four broad modules focusing, respectively, on the following key aspects: What are the nature, scope, and limits of molecular medicine? How does it provide explanations? How does it represent and model phenomena of interest? How does it infer new knowledge from data and experiments? The essays collected here, authored (...) by prominent scientists and philosophers of science, focus on a handful of mainstream topics in the philosophical literature, such as _causation_, _explanation_, _modeling_, and _scientific inference_. These previously unpublished contributions shed new light on these traditional topics by integrating them with problems, methods, and results from three prominent areas of contemporary biomedical science: _basic research_, _translational_ and _clinical research_, and _clinical practice_. (shrink)

Our objective in this paper is twofold: first, we intend to address the tenability of the enactivist middle way between realism and idealism, as it is proposed in The Embodied Mind. We do so by taking the enactivist conception of bringing forth a world literally in three conceptual levels: enaction, niche construction and social construction. Based on this proposal, we claim that enactivism is compatible with the idea of an independent reality without committing to the claim that organisms have cognitive (...) access to a world composed of properties specified prior to any cognitive activity. Our second goal is to show that our literal interpretation of bringing forth a world not only sustains the legitimacy of the middle way, but it also allows us to revive the conception of evolution as natural drift—which is perhaps the least examined aspect of the original enactivist theory and is central to the understanding of cognition in an enactive way. Natural drift focuses on how structural couplings between organism and environment trigger viable pathways of maintenance and reproduction, instead of selecting the most adapted trait to a pregiven environment. Thus, although enactivists typically do not explore the consequences of their views regarding evolutionary dynamics, we show how natural drift provides a suitable starting point. (shrink)

The authors propose some methodological considerations on thanatochronological estimations. They first consider the problem of the definition of death, and then they deal with the issue of the estimations of death time, that is, with the Post-Mortem Interval (PMI). As regards the first question, they note that it does not concern only the definition of death, but also the choice of a particular kind of definition of 'definition'. With reference to the second question, the authors suggest a causal model showing (...) that the presence of many causal chains must be taken into consideration. Finally they discuss what 'most convenient and reliable causal chain' means for a thanatochronologist. (shrink)

Magic and religion are at the origin of the concept of money as a unit for measuring value. Actually, they determined the first forms money took: precious objects, engraved stones, amulets and talismans which conferred a special power, within a social group, on the one who possessed them. In time, this power came to include the power of acquisition in commercial terms, but its original ties with magic were never lost. Aristotle clearly saw the relationship between a certain concept of (...) money (in Politica) and a new ethical concept as a corrective for the imbalances within a social community (in Ethica Nicomachea). If we look closely, we see that this ethical concept is not in opposition to the former but emphasizes the double aspect of the idea of money in antiquity, an idea which has survived, with some modifications, in Christianity and the modern era. (shrink)

I. Introduction Can phenomenology and pragmatism, two early twentieth century theories, be alive today and furnish a valid possibility in our philosophical landscape? Moreover, can they work together? The operation does not seem impossible since Peirce himself held a phenomenology, which is an indispensable part of his never-finished system; James’s psychology is often a phenomenology, and Husserl recognized James as an interesting author because of his phenomenological insights. However, the...

This article offers a comparative exploration of the practices of resistance Theodor Adorno and Michel Foucault champion against the structures of modern power their enquiries have the merit to illuminate and contest. After a preliminary examination of their views about the relationship between theory and praxis, I shall pursue two goals: first, I shall illustrate the limitations of Adorno’s negativist portrait of an ethics of resistance and contrast it with Foucault’s more promising notion of resistance as strategic counter-conduct, which in (...) his late ethico-political writings becomes the heart of a distinctive politics of the governed. Second, despite their dissimilarities, I shall argue that their ideas can be brought together to elaborate a ‘compounded’ account of resistance, where Adorno’s politics of suffering figures as the necessary pre-condition for the creative practices of freedom Foucault seeks to encourage. (shrink)

Esse artigo visa demonstrar como o psicanalista francês Jacques Lacan delineou e reformulou o conceito freudiano de pulsão de morte no interior dos três registros da experiência humana. Dito isso, iremos inicialmente compreender de forma geral como o conceito de pulsão de morte aparece na obra lacaniana, de maneira a demonstrarmos como ela é reformulada pelo autor francês. Depois, iremos delinear como esse conceito aparece no interior dos registros do Imaginário, Simbólico e Real; desse modo, estaremos envoltos com o Estágio (...) do Espelho desenvolvido por Lacan no decorrer dos anos 1930 e 1940, a teoria do significante fundada por nosso autor mais atentamente nos anos 1950 e por último o registro do Real, o qual foi introduzido com mais atenção a partir dos anos 1960 em diante. (shrink)

The aetio-pathogenetic sequences and the physio-pathological patterns of diabetes, emphysema, cholera, circulatory shock and thrombosis have been analysed with respect to an evolutionary interpretation. The diseases, although reflecting alterations of processes that can always be described in physico-chemical language, occur only at the level of biological systems which reflects the decodification of genomic project: the teleonomic projects that have been developed during evolution. The concepts of evolutionary emergence and of downward causation have been used to discuss the relationship between the (...) molecular events responsible for the initiation of the disease, and the subsequent events responsible for the aetio-pathogenesis, for the systemic disarrangement and for the additional alterations of tissues and cells independent of the initial molecular events. In diabetes the systemic disarrangement, glycosuria and hyperglycemia, reflect the evolutionary emergence of the processes regulating carbohydrate metabolism, whereas the cardiovascular and neurological alterations are effects of the systemic disarrangement by a mechanism of downward causation. The complexity of the aetio-pathogenesis and of the physio-pathological patterns of diseases is due to the generation of information during the evolution of multi-hierarchical entities. The evolutionary epistemology approach is useful to explain the behaviour of complex systems. (shrink)

The author investigates the origin and development of the concept of liberty and its special meaning in the Republican tradition of political thought. The origin of the Western concept of liberty lies in ancient Greece, in the opposition between liberty and slavery conceived after the liberation of Athens from tyranny and the victory over the Persian empire. The author then investigates the Republican notion of liberty that originates in ancient Rome and reaches its peak with Cicero. This conception of liberty (...) emphasizes self-government and partecipation in common deliberation and runs through Western political thought up to Rousseau, Tocqueville and the authors of the Federalist Papers. (shrink)